Skip to main content

Lysosomal storage disease in Abyssinian cats

Lysosomal storage disease in Abyssinian cats is apparently well documented. I do not know the frequency of occurrence. Studies indicate that it is inherited through an autosomal recessive gene. The disease is difficult to describe as this is a very technical area. What happens is that a certain enzyme is not produced in a subunit of a cell called a "lysosome". Enzymes break down macromolecules to other substances. If there is no enzyme there is no breakdown and instead the macromolecules are stored. This causes the cells to become dysfunctional. In turn this causes neurological problems the symptoms of which are first noticeable when the kitten is 8-12 weeks old. The first clinical sign is a head quiver. This is followed by ataxia, dysmetria, muscle tremors, in-coordination and an inability to walk. Often kittens will seizure when handled. The symptoms are due to cerebellar disease and the cats die before one year of age. An amorphous material becomes stored in neurons and macrophages.

Lysosomal storage disease in Abyssinian cats - See Wikipedia definitions below of the more difficult terms above. These are reproduced under GNU Free Documentation License, Version 1.2 or any later version - see Wikipedia licensing below

Ataxia meaning "lack of order" is a neurological sign and symptom consisting of gross incoordination of muscle movements.

Dysmetria (Greek: "difficult to measure") refers to a lack of coordination of movement typified by the undershoot and/or overshoot of intended position with the hand, arm, leg, or eye (this refers to people but is equally relevant for cats).

Macrophages (Greek: "big eaters", from makros "large" + phagein "eat") are cells within the tissues that originate from specific white blood cells called monocytes

Wikipedia licensing:
Click on this link to see the Wikipedia® License src: Wikipedia® published under GNU Free Documentation License, Version 1.2 or any later version, November 2002 Copyright (C) 2000,2001,2002 Free Software Foundation, Inc. 51 Franklin St, Fifth Floor, Boston, MA 02110-1301 USA - - no other conditions to the license are added.

Lysosomal storage disease in Abyssinian cats to Abyssinian cats


This comment has been removed by a blog administrator.

Popular posts from this blog

Cat Ear Mites

Brown gunge. Yes, I know this is a ferret! It does show the build up of dark brown to black ear wax caused by the presence of the cat ear mites in the outer ear canal. This parasite is not restricted to the domestic cat, which makes this photo valid and a useful illustration (I was unable to find a suitable photo of a cat with the condition). Photo Stacy Lynn Baum under a creative commons license. Ear mites (minute crab like creatures) are one of the causes of inflammation of the outer ear canal (scientific term for this inflammation is Otitis externa ). The outer ear canal is the tube that runs from outside to the ear drum (the pathway for the reception of sound), which can be seen when looking at the ear. Otitis externa affects humans and often swimmers as it is called "swimmer's ear" in humans. This YouTube video show ear mites under a microscope. They are not actually in the ear in this video. There are many possible causes of Otitis externa in c

Feline Mange

I'll write about three types of feline mange (a) feline scabies or head mange (b) demodectic mange and (c) sarcoptic mange. The source material is from Cat Owner's Home Veterinary Handbook - the best on the market . Generalised feline mange? Puerto Rico - Photo by Gotham City Lost And Found Feline Scabies - head mange Head mange or feline scabies, is a fairly rare condition in cats, which is caused by the Notoedres mite (head mite) that only reproduces on cats. The female mites burrow a few millimeters (that is a lot) into the skin around the head, and neck to lay eggs, which hatch and lay their own eggs. Their presence and activities causes intense itching that in turn causes the cat to scratch. The scratching will obviously be noticed and it will cause the skin to become red, scratched and worse infected. Symptoms: hair loss and scabs, thick wrinkled skin and grey/yellow crusts form plus the symptoms of scratching. Feline mange (head mange) is contagious and tr

Cat Anatomy

Cat Anatomy - Photo by Curious Expeditions . The picture above was taken at Wax Anatomical Models at La Specola in Florence, Italy. The photograph is published under a creative commons license kindly granted by the photographer. I am sorry if it is a bit gruesome. It is pretty well all I could find as an illustration that was licensed for publication. Cat Anatomy is a very wide ranging subject. The anatomy of a cat is very similar to human anatomy. If you were writing a biology book for students of biology you would go through every part of the a cat's anatomy in some detail. It would be similar to writing a book about the human anatomy. It would be a thick book and pretty boring for your average internet surfer. So, how do you limit such a big subject and make this post meaningful? The answer I think lies in doing two things: Having a quick general look at cat anatomy - an overview and; Focusing on the areas of cat anatomy that are particular to the cat and of parti