You can read about feline hyperesthesia on this page. In short cats have times when their skin twitches, their tail whips. Their skin seems sensitive and they don't like being touched. Another symptom is dilated pupils.
The cause could be behavioral or neurological. Science has not yet decided.
It is reported in Cat Owner's Home Veterinary Handbook that Siamese cats suffer from this condition more commonly than average. So do Burmese and Himalayan cat breeds, both of which are related to the Siamese.
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